Average registered nurse compensation in Mississippi across seven career stages — from new grad RN to Chief Nursing Officer. Updated 2026 benchmarks to help you negotiate, plan, and grow.
RN Salary by Role in Mississippi
Mississippi has more modest nursing wages than many states, with staff RNs averaging roughly $60,000 a year, though everyday costs tend to be lower as well.
In Mississippi, compensation grows considerably as nurses gain experience and take on more responsibility. New grad RNs typically start around $44,000, with specialty nurses in units like the ICU, ER, or OR averaging closer to $68,000. Moving into leadership brings a meaningful jump — nurse managers average about $76,000, directors of nursing around $88,000, and chief nursing officers can earn $104,000 or more. For nurses pursuing advanced practice roles (NP, CNS, CRNA, CNM), average pay in Mississippi runs near $76,000.
As a Nurse Licensure Compact member, Mississippi issues multistate RN and LPN licenses to residents, allowing nurses to practice across other compact states without applying for a separate license — a real advantage for travel nursing or remote telehealth work.
Mississippi's lower wages are often paired with a lower cost of living, which can narrow the real-world gap compared to higher-paying states.
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